Late Phase Allergic Reactions Editor
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Early and late allergic reaction in the nose assessed by whole body plethysmography.
Physiological changes during late phase nasal responses after allergen challenge are difficult to establish and different criteria are used for the definition of a positive late phase nasal reaction. The objective of this study was to assess the value of whole body plethysmography in detecting changes in nasal airway resistance after allergen challenge and to suggest criteria for the definition...
متن کاملTitle: Allergic-like Reactions to Asparaginase: Atypical Allergies without Asparaginase Inactivation Authors
Background: Asparaginase is an important component of pediatric acute lymphoblastic leukemia therapy. Unfortunately, this treatment is hampered by hypersensitivity reactions. In general, allergies cause complete inactivation of the drug, regardless of the severity. However, we report atypical allergic reactions without inactivation of asparaginase, here called allergic-like reactions. Procedure...
متن کاملComparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis
BACKGROUND Antihistamines constitute the first line of therapy for allergic conjunctivitis, and are safe and effective in relieving the signs and symptoms of ocular allergy. Despite this, they are less effective than some other drugs in relieving delayed symptoms of allergic conjunctivitis. Recent evidence suggests that changes in the conjunctival epithelium may underlie aspects of delayed reac...
متن کاملExpression of endothelial-leukocyte adhesion molecule-1 in elicited late phase allergic reactions.
To better understand the events involved in the local migration of inflammatory cells into sites of allergic reactions, we studied expression of the cytokine inducible endothelial cell (EC) neutrophil adhesion molecule, endothelial-leukocyte adhesion molecule (ELAM-1), in sequential skin biopsies from patients with respiratory allergy during the late phase reaction (LPR) between 20 min and unti...
متن کاملPhosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation
Mast cells are known to play a pivotal role in allergic diseases. Cross-linking of the high-affinity receptor for IgE (FcepsilonRI) leads to degranulation and allergic inflammation; however, the regulatory mechanisms of IgE-dependent exocytosis remain unknown. We show here that IkappaB kinase (IKK) 2 in mast cells plays critical roles in IgE-mediated anaphylaxis in vivo, and IgE-mediated degran...
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